IVF treatments,

  • Embryo Glue

     

    IVF technology is considered one of the most useful technical and scientific procedures today for having a baby and itoffers the highest chance of success per cycle.

    Certainly, the success of in vitro fertilization and embryo transfer (IVF-ET) is contributed by many factors, which include the couples' profile, uterine pathology, drug protocols, laboratory conditions, embryo quality and embryo transfer technique. Implantation of the embryo still remains the key factor for IVF success. For implantation to occur, a genetically normal blastocyst (day 5 embryo) should attach and invade a well-synchronized endometrium, under the influence of Oestrogen and Progesterone hormones. 

    However, repeated implantation failure despite of transfer of good-quality embryos still continues to be a dilemma. The implementation of effective and simple treatment protocol for a satisfactory pregnancy rate in assisted reproduction is very important especially in the case of previous unsuccessful attempts.

    Since the beginning of successful IVF trials, multiple researches were done in an attempt to increase the success rate for a healthy pregnancy and delivery.

    One of these researches that were declared on isEmbryo Glue(1-5 ).

    As its name suggests, EmbryoGlue is claimed to increase the rate at which embryos implant or stick to the uterus after transfer.

    What is embryo glue?

    Traditionally, the medium that is used for embryo transfer has been similar or identical to the solution used for growing the embryos. However, the introduction of EmbryoGlue is purported to bring about a dramatic increase in the rate at which embryos implant after transfer.

    There may be several important points to the use of EmbryoGlue. The key component is an enzyme called hyaluronan, which has been shown to increase rates of implantation and fetal development in humans. Hyaluronan is naturally found enzyme in follicular fluids, the fallopian tubes and the uterus, so it is thought to provide a more ‘natural’ environment for the embryos. Hyaluronan production in the uterus is at its highest at the time of embryo implantation, and the enzyme promotes cell to cell contact between the embryo and the uterus. It also dilates the uterine blood vessels, increasing blood supply to the uterus. Lastly, hyaluronan is a viscous sticky solution that more closely resembles the natural secretions of the uterus.

    This material is responsible for preparing the uterus to receive the fetus just before implantation and during incubation.It also contains other nutrients such as albumin, water and bicarbonates, all these ingredients helps to nourish the fetus from the moment of transfer till implantation.In conclusion, embryo glue seems to increase the pregnancy rate as compared to cases without using embryo glue, and it helps also in the continuity of pregnancy.

    The success stories about embryo glue are encouraging. It’s still relatively new. Research into its benefits is continuing. But if you’ve had failed IVF attempts, or issues with implantation, we recommend using it in addition to standard IVF.

     

    References

    1.Singh N, Gupta M, Kriplani A, Vanamail P. Role of Embryo Glue as a transfer medium in the outcome of fresh non-donor in-vitro fertilization cycles. J Hum Reprod Sci. 2015 Oct-

    Dec;8(4):214-7.

    2.Malojerdi MR. Efficacy of a human embryo transfer medium: a prospective,randomized clinical trial study. J Asist Reprod Genet 2006;23 (5) 207-212.

    3.Balaban B, Isiklar A, Yakin K, Gursoy H, Urman B. Increased implantation rates in patients with recurrent implantation failures following the use a new transfer medium enriched with hyaluronan. Hum Reprod Suppl. 2004;19:7.

    4.Schoolcraft W, Lane M, Stevens J, Gardner DK. Increased hyaluronan concentration in the embryo transfer medium results in a significant increasein human embryo implantation rate.Fertil Steril.2002;76(Suppl 3):S5.

    5.Saito H, Kaneko T, Takahashi T, Kawachiya S, Saito T, Hiroi M. Hyaluronan in follicular fluids and fertilization of oocytes. Fertil Steril. 2000;74:1148–52.

     

     

  • Embryo transfer on Day 3 or Day 5? Which is better for a successful pregnancy ?

    One of the common questions that patients ask about IVF is the difference between doing an embryo transfer on Day 3 or Day 5 following egg pick up. To answer this, we should know a little about the reproduction physiology. When a woman conceives naturally, fertilization occurs in her fallopian tubes. It takes about 3 to 4 days for the fertilized egg to travel through the fallopian tube to the endometrial cavity of the uterus ( mother’s womb). During the transit of the fertilized egg (called a zygote at that stage), the zygote divides into an embryo (by day 2-3) and then further divides to a morula (by day 4) prior to arriving/implanting in the uterus. So, by the time the pregnancy implants in the uterus, it's at a stage of development called a blastocyst on day 5.

    Investigations on this field show that blastocyst transfer (day 5) during IVF treatments results in a significantly higher chance of pregnancy compared to an embryo transfer on day 3.

    We have routinely been performing blastocyst culture and transfer for many years and observe significantly higher implantation and pregnancy rates as compared to what we see with day 3 embryos. First of all, it could be that longer incubation of embryos in the laboratory allows healthier embryos to grow, while those that are not healthy generally stop growing. This would increase the likelihood that better quality embryos would be chosen and transferred into the patient’s uterus, potentially increasing the chance for pregnancy. Another possible reason is that it more physiologically mimics that which occurs in nature during a spontaneous pregnancy. IVF labs which have poorer techniques and personnel, tend to favour day 3 transfers, as they may not be able to nurture the growing embryos for 5 days. However, if a very limited number of embryos are available on day 3 and no embryo selection is required, then the benefit of a day-5embryo transfer may be limited to the improved synchronization between embryo and endometrium. Because it is obvious that the best conditioned place for the embryos is the mother’s womb itself.

    Finally, a clinic’s success with embryo cryopreservation following extended culture should also be carefully considered. We believe that extended culture to day 5 must go hand in hand with an excellent cryopreservation program in order to maximize patient success.

     

     

  • IVF Packages

    ivf doctors

     

    Option1:Package contains the IVF/ICS procedure, AHA and IMSI in necessary cases, all hormone tests and consultations during follow up period,  and embryo transfer.

    Option2: Package contains  the IVF/ICSI procedure, AHA and IMSI in necessary cases, all hormone tests and consultations during follow up period , freezing the extra embryos and storage for one year, all the drugs and medications until embryo replacement and also 20 night accommodation and airport transfers.

     

     Yelda Sertbaş
    International Patient Relations
    IVF Department
    Medicana International Istanbul

     

    http//www.ivftreatment.org
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    Phone:+90 0212 867 79 38

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